Osteoprotegerin (TNFRSF11B) Goat Polyclonal Antibody

CAT#: AP31589PU-N

Osteoprotegerin (TNFRSF11B) goat polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: ELISA: 1 µg/ml.
• Reactivities: Human
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Purified recombinant Human Osteoprotegerin
• Specificity: Recognizes Human Osteoprotegerin. Other species not tested.
• Formulation: PBS, pH 7.4
  State: Aff - Purified
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore in aqua bidest to 1 mg/ml
• Purification: Affinity Chromatography using Human OPG
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens tumor necrosis factor receptor superfamily member 11b (TNFRSF11B)
• Database Link:
  Entrez Gene 4982 Human
• Background: Bone morphogenesis and remodeling involve the formation of bone from osteoblasts and the resorption of bone by osteoclasts. The cytokine osteoprotegerin (OPG), also designated Osteoclastogenesis Inhibitory Factor (OCIF), is known to inhibit osteoclast formation. A secreted glycoprotein, OPG is a member of the TNF receptor family that increases bone density and volume. OPG is thought to inhibit osteoclastogenesis by disrupting the cell-to-cell signaling between osteoblastic stromal cells and osteoclast progenitors. OPG is known to bind to TRAIL, a death domain-containing protein, and to inhibit TRAIL apoptosis in Jurkat cells. OPG also binds to osteoclast differentiation factor (ODF), also known as TRANCE/RANKL, a membrane-bound protein belonging to the TNF ligand family. Both TNFα and TNFβ upregulate OPG expression, while the bone resorbing agent prostaglandin E2 downregulates OPG.
• Synonyms: OPG, OCIF

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction