PGP9.5 (UCHL1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP31608PU-N

PGP9.5 (UCHL1) (C-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of extracts from 293 cells, using PGP9.5 Antibody. The lane on the right is treated with the synthesized peptide.

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  Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/5000.
  Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated
• Specificity: This antibody detects endogenous levels of total PGP9.5 protein.
• Formulation: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody (in aliquots) at -20°C.
  Avoid freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens ubiquitin C-terminal hydrolase L1 (UCHL1)
• Database Link:
  Entrez Gene 22223 MouseEntrez Gene 29545 RatEntrez Gene 7345 Human
• Background: UCHL1 is a member of family of proteins that hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. The expression of UCHL1 is highly specific to neurons and to cell of the diffuse neuroendocrine system and their tumors. UCHL1 exhibits both and hydrolase and a ligase activity. The S18Y variant of UCHL1, that has reduced ligase activity, has been linked to susceptibility for Parkinson's disease.
• Synonyms: UCH-L1, PGP 9.5, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Parkinson's disease