DARC (ACKR1) (1-50) Rabbit Polyclonal Antibody

CAT#: AP31626PU-N

DARC (ACKR1) (1-50) rabbit polyclonal antibody, Aff - Purified

Product Images

Human Thymus, Vessels: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence analysis of A549 cells, using CD234 Antibody (left). The picture on the right is treated with the synthesized peptide.

Specifications

Product Data

• Applications: ELISA, IF, IHC
• Recommended Dilution: ELISA: 1/40000.
  Immunofluorescence: 1/100 - 1/500.
  Immunohistochemistry on Paraffin Sections: 1/200.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from human DARC (aa 1-50)
• Specificity: This antibody detects endogenous levels of total CD234 protein.
• Formulation: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody (in aliquots) at -20°C or lower.
  Avoid freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens atypical chemokine receptor 1 (Duffy blood group) (ACKR1), transcript variant 1
• Database Link:
  Entrez Gene 2532 Human
• Background: Duffy blood group antigens, part of the Chemokine Receptor family, appear to be multimeric erythrocyte-membrane protein receptors composed of different subunits. A glycoprotein, GPD, is the major subunit of the protein complex. Other components include the Rh, PGM1, Fy, and PEPC proteins. Duffy antigen is expressed by red blood cells, by postcapillary venule endothelium throughout the body, except in the liver, and by Purkinje cells of the cerebellum. Duffy negativity (lack of Duffy expression in bone marrow) has been linked to protection against malaria. In erythrocytes, the chemokines interleukin-8 and melanoma growth stimulatory activity (MGSA) activate Duffy antigen.
• Synonyms: Duffy antigen/chemokine receptor, Fy glycoprotein, GpFy, Glycoprotein D, FY, GPD

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane