Tek Rabbit Polyclonal Antibody

CAT#: AP31728PU-L

Tek rabbit polyclonal antibody, Purified


USD 385.00

2 Weeks*

Size
    • 200 ug

Product Images

Specifications

Product Data
Applications FC, WB
Recommended Dilution Western Blot: 2-5 μg/ml. 
Flow Cytometry: 1-5 μg/ml.
Reactivities Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Highly pure (>95%) recombinant Mouse soluble TIE-2 (Ala23-Ala737) derived from Insect cells.
Specificity Recognizes TIE-2 (CD202b/TEK)
Formulation PBS, pH 7.2
State: Purified
State: Liquid purified IgG fraction
Purification Protein A Chromatography
Gene Name Homo sapiens TEK receptor tyrosine kinase (TEK), transcript variant 1
Background Recombinant Mouse soluble TIE-1 was fused with a 6x His-tag at the C-terminus. The soluble receptor protein consists of the full extracellular domain (Ser22-Ala748). Mouse sTIE-1 monomer has a calculated molecular mass of approximately 79,8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 95 kDa protein in SDS-PAGE under reducing conditions. TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region.
These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.
Synonyms TIE2, TIE-2, Angiopoietin-1 receptor, p140 TEK
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.