Amyloid Fibrils (OC) Rabbit Polyclonal Antibody

CAT#: AP31731PU-N

Amyloid Fibrils (OC) rabbit polyclonal antibody, Purified


USD 400.00

5 Days*

Size
    • 100 ul

Specifications

Product Data
Applications ELISA, IF, IHC, IP, WB
Recommended Dilution Dot Blot: 1/1000.
A 1/1000 dilution of AP31731PU-N was sufficient for detection of Amyloid fibrils on PVDF membranes using transferred fibrils by colorimetric dot blot analysis using Goat anti-Rabbit IgG:HRP as the secondary antibody.
Cited Applications: 
ELISA, Immunocytochemistry, Immunoprecipitation, Immunohistochemistry and Western Blot, Dot Blot.
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fibrils prepared from Human Aß42 peptide.
Specificity This antibody recognizes generic epitopes common to many Amyloid fibrils and fibrillar oligomers, but not prefibrilllar oligomers or natively folded proteins.
Formulation PBS
State: Purified
State: Liquid purified IgG fraction
Stabilizer: 50% Glycerol
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Protein A Chromatography
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Background Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer’s symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington’s disease (2, 3).
Synonyms OC, Fibrils
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.