Factor IX (F9) Sheep Polyclonal Antibody

CAT#: AP31735PU-N

Factor IX (F9) sheep polyclonal antibody, Ig Fraction

Product Images

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, Ie, IHC
• Recommended Dilution: ELISA.
  Immunoelectrophoresis.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
• Reactivities: Human
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Human Factor IX purified from plasma.
• Specificity: Recognizes Human Factor IX as demonstrated by Immunodiffusion. A single positive reactivity band was observed with Normal Human Plasma.
  No reaction was observed against Factor IX-deficient plasma.
• Formulation: 0.01M HEPES, pH 7.4, 0.1M Sodium Chloride and 50% Glycerol
  State: Ig Fraction
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Ammonium Sulfate Precipitation
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens coagulation factor IX (F9), transcript variant 1
• Database Link:
  Entrez Gene 2158 Human
• Background: Coagulation Factor IX (F9) circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.
• Synonyms: Christmas factor, PTC

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades