ACK1 (TNK2) Rabbit Polyclonal Antibody

CAT#: AP31749PU-N

ACK1 (TNK2) rabbit polyclonal antibody, Purified

Product Images

• 

  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/16000.
  Immunohistochemistry on Paraffin Sections: 1.25 µg/ml.
  Western Blot: 1/500.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide.
  Epitope: Amino acids 278-289
• Specificity: Recognizes TNK2 / ACK1
• Formulation: PBS, pH 7.4 containing 0.05% Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1 mg/ml
• Gene Name: Homo sapiens tyrosine kinase non receptor 2 (TNK2), transcript variant 2
• Database Link:
  Entrez Gene 51789 MouseEntrez Gene 303882 RatEntrez Gene 10188 Human
• Background: ACK encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation pathway.
• Synonyms: ACK; ACK-1; ACK1; FLJ44758; FLJ45547; p21cdc42Hs

Reference Data

• Protein Families: Druggable Genome, Protein Kinase