C1R Rabbit Polyclonal Antibody

CAT#: AP31757PU-N

C1R rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from 293/A549 cells, treated with etoposide 25uM 1h, using. The lane on the right is treated with the synthesized peptide.

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  Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/20000.
  Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from Human C1R.
  Epitope: Amino Acids 445-494.
• Specificity: This antibody detects endogenous levels of fragment of activated C1R resulting from cleavage adjacent to Ile464.
• Formulation: PBS (without Mg²⁺, Ca²⁺), pH 7.4, 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement component 1, r subcomponent (C1R)
• Database Link:
  Entrez Gene 715 Human
• Background: C1 component of human complement is a complex of three glycoproteins: C1q, C1r and C1s. C1r has a molecular weight of 83,000 and is present in plasma in an average concentration of 50 mg/ml, either as a complex with C1q and C1s or in the absence of C1q as a tetramer with C1s.
  The subcomponents of the C1 complex are responsible for the initiation of the classical pathway of complement activation.
• Synonyms: Complement C1r, Complement 1r

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Complement and coagulation cascades, Systemic lupus erythematosus