Osteoprotegerin (TNFRSF11B) Rabbit Polyclonal Antibody

CAT#: AP31765PU-N

Osteoprotegerin (TNFRSF11B) rabbit polyclonal antibody, Aff - Purified

Product Images

Human Pancreas, Exocrine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/20000 - 1/80000.
  Immunohistochemistry on Paraffin Sections: 2 µg/ml.
  Western Blot: 1/200 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide
• Formulation: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens tumor necrosis factor receptor superfamily member 11b (TNFRSF11B)
• Database Link:
  Entrez Gene 4982 Human
• Background: TNFRSF11B, a member of the TNF-receptor superfamily, is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. TNFRSF11B specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification.
• Synonyms: OPG, OCIF

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction