HSD11B1 Rabbit Polyclonal Antibody

CAT#: AP31830PU-N

HSD11B1 rabbit polyclonal antibody, Aff - Purified

Product Images

Formalin-Fixed, Paraffin-Embedded Human Lung, Macrophages stained with HSD11B1 antibody

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/100.
  Western Blot: 1/500 - 1/3000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide
• Specificity: This Polyclonal antibody is directed against human 11-Hydroxysteroid Dehydrogenase(Type 1)protein.
  Expect reactivity with Human 11-Hydroxysteroid Dehydrogenase(Type 1).
  Cross-reactivity with 11-Hydroxysteroid Dehydrogenase (Type 1) from other sources has not been determined.
• Formulation: PBS, pH 7.4 containing 0.02% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant 3
• Database Link:
  Entrez Gene 15483 MouseEntrez Gene 25116 RatEntrez Gene 3290 Human
• Background: HSD11B1 Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
  Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
• Synonyms: 11-beta-hydroxysteroid dehydrogenase 1, HSD11, HSD11L, 11-DH

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways