CTDSP1 Goat Polyclonal Antibody

CAT#: AP31837PU-N

CTDSP1 goat polyclonal antibody, Aff - Purified


USD 375.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution Peptide ELISA: 1/16000 (Detection Limit).
Western blot: 0.1-0.3 µg/ml. Approx 30kDa band observed in Mouse Testis lysates (calculated MW of 29.3kDa according to Mouse NP_694728.1).
Reactivities Bovine, Canine, Human, Mouse, Rat
Host Goat
Clonality Polyclonal
Immunogen Peptide with sequence from the internal region of the protein sequence according to NP_067021.1; NP_872580.1.
Specificity This antibody is expected to recognise both reported isoforms (NP_067021 and NP_872580).
Formulation Tris buffered saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration 0.5 mg/ml
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
Gene Name Homo sapiens CTD small phosphatase 1 (CTDSP1), transcript variant 3
Background CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.
Synonyms NIF3, NLIIF, SCP1, NLI-interacting factor 3, NLI-IF
Reference Data
Protein Families Phosphatase

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