Paralemmin (PALM) Rabbit Polyclonal Antibody

CAT#: AP31901PU-N

Paralemmin (PALM) rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution:

  ELISA.
  Western Blot: 1/200-1/5000.
  Immunohistochemistry: 1/100-1/2000.

• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from internal part of Human PALM protein.
• Specificity: This antibody reacts with Paralemmin-1
• Formulation: Tris 0,1M, glycine 0,1M, sucrose 2%
  State: Purified
  State: Lyohilized purified IgG fraction
  Preservative: None
• Reconstitution Method: Restore in distilled water.
• Purification: Affinity Chromatography on Protein A
• Storage:

  Lyophilized powder stable for a minimum of 2 years at -20°C.
  Store reconstituted antibody at 2-4°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: Six months from despatch.

• Database Link:
  Entrez Gene 5064 Human
• Background: Paralemmin, also called Paralemmin-1 or PALM, is a widely expressed peripheral membrane protein that is involved in cell structure and shape. A hydrophobic protein, Paralemmin is anchored to the cytoplasmic side of the cell membrane via di-palmitoylation and prenylation of its C-terminal cysteine cluster. Functioning at the synapse to regulate neuronal plasticity and plasma membrane dynamics, Paralemmin can bind to the dopamine receptor D3, thereby reducing D3 expression and subsequent adenylate cyclase activity. Overexpression of Paralemmin induces fibroblasts to extend long filopodia and to assume extreme cell shapes, suggesting involvement in the formation and stabilization of the plasma membrane. Two isoforms of Paralemmin exists due to alternative splicing events.
• Synonyms: Paralemmin, KIAA0270