Drebrin (DBN1) (1-326) Mouse Monoclonal Antibody [Clone ID: DBN-N-03]

CAT#: AP32304RP-N

Drebrin (DBN1) (1-326) mouse monoclonal antibody, clone DBN-N-03, PE

Product Images

Surface staining (mass cytometry) of brain tumor cells with anti-drebrin (DBN-N-03) 152Sm. Gated on singlets.

Specifications

Product Data

• Clone Name: DBN-N-03
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of Human blood cells using 4 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension.
  The content of a vial (0.4 ml) is sufficient for 100 Tests.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
• Specificity:

  This Monoclonal antibody DBN-N-03 recognizes Drebrin, an approximately 100-125 kDa regulator of actin cytoskeleton.

• Formulation: PBS
  Label: PE
  State: Liquid purified IgG fraction
  Stabilizer: 0.2% (w/v) high-grade protease free BSA
  Preservative: 15 mM Sodium Azide
  Label: Phycoerythrin
• Purification: Size-Exclusion Chromatography and adjusted for direct use. No reconstitution is necessary.
• Conjugation: PE
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  This products is photosensitive and should be protected from light.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 1627 Human
• Background: Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.
• Synonyms: DBN1, DBN-1, D0S117E, DKFZp434D064,drebrin 1