Drebrin (DBN1) (1-326) Mouse Monoclonal Antibody [Clone ID: DBN-N-03]

CAT#: AP32304RP-N

Drebrin (DBN1) (1-326) mouse monoclonal antibody, clone DBN-N-03, PE


USD 300.00

2 Weeks*

Size
    • 100 Tests

Product Images

Specifications

Product Data
Clone Name DBN-N-03
Applications FC
Recommended Dilution Flow Cytometry analysis of Human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension.
The content of a vial (0.4 ml) is sufficient for 100 Tests.
Reactivities Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
Specificity

This Monoclonal antibody DBN-N-03 recognizes Drebrin, an approximately 100-125 kDa regulator of actin cytoskeleton.

Formulation PBS
Label: PE
State: Liquid purified IgG fraction
Stabilizer: 0.2% (w/v) high-grade protease free BSA
Preservative: 15 mM Sodium Azide
Label: Phycoerythrin
Purification Size-Exclusion Chromatography and adjusted for direct use. No reconstitution is necessary.
Conjugation PE
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
This products is photosensitive and should be protected from light.  
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.
Synonyms DBN1, DBN-1, D0S117E, DKFZp434D064,drebrin 1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.