TIMP3 (175-211) Rabbit Polyclonal Antibody
Specifications
Product Data | |
Applications | FC, IF, IHC, IP, WB |
Recommended Dilution | Flow Cytometry: 0.5-1 µg/106 cells. Immunofluorescence: 1-2 µg/ml. Western Blotting: 0.5-1 µg/ml. Immunoprecipitation: 1-2 µg/500 µg protein lysate. Immunohistochemistry on Formalin-Fixed Paraffin Sections: 1/200-1/400 for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes. Positive Control: Placenta or breast carcinoma. |
Reactivities | Bovine, Canine, Equine, Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | A portion of amino acids 175-211 of Human TIMP3 |
Specificity | This antibody recognizes TIMP-3 (Tissue Inhibitor of Metalloproteinase-3). |
Formulation | 10mM PBS State: Purified State: Liquid purified IgG fraction from Serum Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide |
Concentration | lot specific |
Purification | Protein A Chromatography |
Storage | Store undiluted at 2-8°C. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | 30 kDa |
Database Link | |
Background | TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP’s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. |
Synonyms | Protein MIG-5, TIMP-3 |
Reference Data |
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