gamma Catenin (JUP) (N-term, 5-21) Guinea Pig Polyclonal Antibody

CAT#: AP33204SU-N

gamma Catenin (JUP) (N-term, 5-21) guinea pig polyclonal antibody, Serum

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunoblotting (Western blot): 1/2000.
  Immunohistochemistry on Frozen Sections: 1/100.
  Immunohistochemistry on Paraffin Sections: 1/50 (after microwave treatment).
  Cytological Material.
  Incubation Time: 1 h at RT extended with paraffin sections.
• Reactivities: Human, Mouse
• Host: Guinea Pig
• Clonality: Polyclonal
• Immunogen: Synthetic N-terminus of Human Plakoglobin (aa 5-21), identical to gamma-Catenin
• Specificity: Specific detection of Mr 83 000 Plakoglobin, "band 5" polypeptide of intercellular adhering junctions (also described as Gamma-Catenin).
  Excellent marker for all forms of intercellular adhering junctions, such as: desmosomes of epithelial and myocardial cells (incl. cultured cells); zonulae and fasciae adherentes of epithelia, endothelia of blood vessels and myocardial cells; adherens-type junctions (e.g. lens tissue, pigmented retinal cells, Sertoli cells of testis).
  Especially useful for studying plakoglobin mutations in cardiomyopathies (e.g. ARVC, see References below).
• Formulation: State: Serum
  State: Liquid prediluted stabilized antiserum
  Preservative: 0.09% Sodium Azide
• Storage: Store undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 3728 Human
• Background: Gamma Catenin is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of gamma Catenin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. It is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.
• Synonyms: Desmoplakin-3, Desmoplakin III, Catenin gamma, JUP, CTNNG, DP3