GBA (C-term) Rabbit Polyclonal Antibody

CAT#: AP46301PU-N

GBA (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Human, Rat; WB Suggested Anti-GBA Antibody Primary: 1:1000. Positive Control: rat organs, fibroblasts, HeLa cell lysate; GBA antibody - C-terminal region (AP46301PU-N) in Human, Rat cells using Western Blot

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  Human MDA-MB435; WB Suggested Anti-GBA Antibody Titration: 1 ug/ml. Positive Control: MDA-MB-435S cell lysate. GBA is strongly supported by BioGPS gene expression data to be expressed in Human MDA-MB435 cells.; GBA antibody - C-terminal region (AP46301PU-N) in Human MDA-MB435 cells using Western Blot

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  Western blotting (0.2 - 1 µg/ml)

• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide directed towards the C-term region of human Glucosylceramidase
• Formulation: State: Aff - Purified
  State: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Purification: Purified using peptide immunoaffinity column
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: glucosylceramidase beta
• Database Link:
  NP_000148
  Entrez Gene 2629 Human
• Background: This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
• Synonyms: Beta-glucocerebrosidase, Alglucerase, Imiglucerase, GBA, GC, GLUC, Acid beta-glucosidase

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism