ALKBH1 (N-term) Rabbit Polyclonal Antibody

CAT#: AP46320PU-N

ALKBH1 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Human Fetal Kidney; WB Suggested Anti-ALKBH1 Antibody. Titration: 1.0 ug/ml. Positive Control: Fetal Kidney; ALKBH1 antibody - N-terminal region (AP46320PU-N) in Human Fetal Kidney cells using Western Blot

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  Western blotting (0.2 - 1 µg/ml).

• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a N-terminal region of human ALKBH1
• Formulation: State: Aff - Purified
  State: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Purification: Immunoaffinity column
• Predicted Protein Size: ALX1: 37 kDa
• Gene Name: Homo sapiens alkB homolog 1, histone H2A dioxygenase (ALKBH1)
• Database Link:
  Entrez Gene 8846 Human
• Background: ALKBH1 is a dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. This requires molecular oxygen, alpha-ketoglutarate and iron. ALKBH1 may have a role in placental trophoblast lineage differentiation, has DNA lyase activity and introduces double-stranded breaks at abasic sites. It cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.
• Synonyms: ALKBH, ABH