Serotonin N acetyltransferase (AANAT) (N-term) Rabbit Polyclonal Antibody

CAT#: AP50011PU-N

Serotonin N acetyltransferase (AANAT) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of AANAT Antibody (N-term) in Y79 cell line lysates (35 ug/lane). AANAT (arrow) was detected using the purified Pab

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western blotting: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 33~63 amino acids from the N-terminal region of human AANAT
• Specificity: This antibody reacts to Serotonin acetylase.
• Formulation: PBS containing 0.09% (W/V) sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens aralkylamine N-acetyltransferase (AANAT), transcript variant 2
• Database Link:
  Entrez Gene 15 Human
• Background: AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.
• Synonyms: AANAT, AA-NAT, SNAT, Serotonin N-acetyltransferase
• Note: Molecular Weight: 23344 Da

Reference Data

• Protein Pathways: Metabolic pathways, Tryptophan metabolism