AKR1C3 (N-term) Rabbit Polyclonal Antibody

CAT#: AP50133PU-N

AKR1C3 (N-term) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications FC, WB
Recommended Dilution ELISA: 1/1000.
Western blotting: 1/1000.
Flow Cytometry: 1/10 - 1/50.
Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human AKR1C3
Specificity This antibody reacts to AKR1C3.
Formulation PBS containing 0.09% (W/V) sodium azide as preservative
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Affinity chromatography on Protein A
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens aldo-keto reductase family 1, member C3 (AKR1C3), transcript variant 1
Background This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms HSD17B5, KIAA0119, PGFS, Dihydrodiol dehydrogenase 3, 3-alpha-HSD type II, 17-beta-hydroxysteroid dehydrogenase type 5
Note Molecular Weight: 36853 Da
Reference Data
Protein Families Druggable Genome
Protein Pathways Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P450

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.