Apc5 (ANAPC5) (Center) Rabbit Polyclonal Antibody

CAT#: AP50172PU-N

Apc5 (ANAPC5) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

ANAPC5 Antibody (Center) western blot analysis in A549 cell line lysates (35 ug/lane).This demonstrates the ANAPC5 antibody detected the ANAPC5 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western blotting: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human ANAPC5
• Specificity: This antibody reacts to APC5.
• Formulation: PBS containing 0.09% (W/V) sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens anaphase promoting complex subunit 5 (ANAPC5), transcript variant 1
• Database Link:
  Entrez Gene 51433 Human
• Background: This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
• Synonyms: Anaphase-promoting complex subunit 5
• Note: Molecular Weight: 85077 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis