Angiopoietin like 4 (ANGPTL4) (Center) Rabbit Polyclonal Antibody

CAT#: AP50178PU-N

Angiopoietin like 4 (ANGPTL4) (Center) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of ANGPTL4 Antibody (Center) in mouse liver tissue lysates (35ug/lane). ANGPTL4 (arrow) was detected using the purified Pab.

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  Formalin-fixed and paraffin-embedded human skeletal muscle reacted with ANGPTL4 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

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  ANGPTL4 Antibody (Center) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western blotting: 1/50 - 1/100.
  Immunohistochemistry: 1/50 - 1/100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 145~175 amino acids from the Center region of human ANGPTL4
• Specificity: This antibody reacts to ANGPTL4.
• Formulation: PBS containing 0.09% (W/V) sodium azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens angiopoietin like 4 (ANGPTL4), transcript variant 3
• Database Link:
  Entrez Gene 57875 MouseEntrez Gene 51129 Human
• Background: ANGPTL4 is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This protein is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes.
• Synonyms: Angiopoietin-related protein 4, Angiopoietin-like 4, ARP4, HFARP, PGAR, Fasting-induced adipose factor
• Note: Molecular Weight: 45214 Da

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: PPAR signaling pathway