Silencer of Death Domain (BAG4) (C-term) Rabbit Polyclonal Antibody

CAT#: AP50336PU-N

Silencer of Death Domain (BAG4) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

BAG4 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the BAG4 antibody detected the BAG4 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western blotting: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 380-409 amino acids from the C-terminal region of human BAG4
• Specificity: This antibody reacts to BAG4.
• Formulation: PBS containing 0.09% (W/V) sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens BCL2 associated athanogene 4 (BAG4), transcript variant 1
• Database Link:
  Entrez Gene 9530 Human
• Background: BAG4 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.
• Synonyms: BAG-4, SODD
• Note: Molecular Weight: 49594 Da

Reference Data

• Protein Families: Druggable Genome