delta 2 Catenin (CTNND2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP51127PU-N

delta 2 Catenin (CTNND2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

CTNND2 Antibody (C-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CTNND2 antibody detected the CTNND2 protein (arrow).

• 

  CTNND2 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the CTNND2 antibody detected the CTNND2 protein (arrow).

• 

  CTNND2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CTNND2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Peptide ELISA: 1/1000.
  Western Blot: 1/1000.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 1131-1159 amino acids from the C-terminal region of Human CTNND2
• Specificity: This antibody reacts to CTNND2.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) Sodium Azide
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 132656 Da
• Gene Name: Homo sapiens catenin delta 2 (CTNND2), transcript variant 1
• Database Link:
  Entrez Gene 18163 MouseEntrez Gene 1501 Human
• Background: This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.
• Synonyms: CTNND2, NPRAP, Delta-catenin, Neurojungin, GT24

Reference Data

• Protein Families: Druggable Genome