Cathepsin K (CTSK) (Center) Rabbit Polyclonal Antibody

CAT#: AP51131PU-N

Cathepsin K (CTSK) (Center) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of CTSK (arrow) using CTSK Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CTSK gene.

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  Formalin fixed and paraffin embedded human skeletal muscle stained with CTSK Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining.

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  Cathepsin K Antibody flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/1000
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
  Flow Cytometry: 1/10-1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 96-126 amino acids from the Central region of Human Cathepsin K
• Specificity: This antibody recognizes Human Cathepsin K.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) Sodium Azide
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) Precipitation
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 36966 Da
• Gene Name: Homo sapiens cathepsin K (CTSK)
• Database Link:
  Entrez Gene 1513 Human
• Background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq].
• Synonyms: Cathepsin O, Cathepsin X, Cathepsin O2, CTSK, CTSO, CTSO2

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Lysosome