DCC (Center) Rabbit Polyclonal Antibody

CAT#: AP51195PU-N

DCC (Center) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

Product Images

Specifications

Product Data
Applications IHC, WB
Recommended Dilution ELISA: 1/1000.
Western Blot: 1/100-1/500. 
Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivities Human, Mouse
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 642-670 amino acids from the Central region of Human DCC.
Specificity This antibody recognizes Human and Mouse DCC (Center).
Formulation PBS
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Affinity Chromatography on Protein A
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Gene Name Homo sapiens DCC netrin 1 receptor (DCC)
Background
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Synonyms IGDCC1, Tumor suppressor protein DCC, Colorectal cancer suppressor, CRC18, CRCR1
Note Molecular Weight: 158457 Da
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Axon guidance, Colorectal cancer, Pathways in cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.