Dishevelled 2 (DVL2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP51345PU-N

Dishevelled 2 (DVL2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Dishevelled-2 / DVL2 Antibody (C-term) in CEM cell line lysates (35ug/lane). This demonstrates the DVL2 antibody detected the DVL2 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 587-617 amino acids from the C-terminal region of Human DVL2.
• Specificity: This antibody recognizes Human Dishevelled-2 / DVL2 (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens dishevelled segment polarity protein 2 (DVL2)
• Database Link:
  Entrez Gene 1856 Human
• Background: This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
• Synonyms: DVL-2, DSH homolog 2
• Note: Molecular Weight: 78948 Da

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Melanogenesis, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway