ERCC8 (Center) Rabbit Polyclonal Antibody

CAT#: AP51450PU-N

ERCC8 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of ERCC8 Antibody in mouse spleen tissue lysates (35ug/lane). This demonstrates the ERCC8 antibody detected the ERCC8 protein (arrow).

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  Formalin fixed and paraffin embedded human lung carcinoma reacted with ERCC8 Antibody followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/50-1/100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 210-238 amino acids from the Central region of Human ERCC8
• Specificity: This antibody recognizes Human and Mouse ERCC8 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens ERCC excision repair 8, CSA ubiquitin ligase complex subunit (ERCC8), transcript variant 1
• Database Link:
  Entrez Gene 71991 MouseEntrez Gene 1161 Human
• Background: This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
• Synonyms: CKN1, CSA, ERCC-8
• Note: Molecular Weight: 44055 Da

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Nucleotide excision repair, Ubiquitin mediated proteolysis