HEXO (ERI1) (N-term) Rabbit Polyclonal Antibody

CAT#: AP51455PU-N

HEXO (ERI1) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of ERI1 / THEX1 (N-term) Antibody (N-term) in 293 cell line lysates (35ug/lane). This demonstrates the ERI1 antibody detected the ERI1 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 79-109 amino acids from the N-terminal region of Human ERI1
• Specificity: This antibody recognizes Human ERI1 / THEX1 (N-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens exoribonuclease 1 (ERI1)
• Database Link:
  Entrez Gene 90459 Human
• Background: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
• Synonyms: 3'-5' exoribonuclease 1, 3'EXO, HEXO
• Note: Molecular Weight: 40064 Da