FGD4 (N-term) Rabbit Polyclonal Antibody

CAT#: AP51651PU-N

FGD4 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

FGD4 Antibody (N-term) western blot analysis in human normal Uterus cell line lysates (35ug/lane).This demonstrates the FGD4 antibody detected the FGD4 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 156-186 amino acids from the N-terminal region of human FGD4
• Specificity: This antibody reacts to FGD4.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 86626 Da
• Gene Name: Homo sapiens FYVE, RhoGEF and PH domain containing 4 (FGD4), transcript variant 3
• Database Link:
  Entrez Gene 121512 Human
• Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq].
• Synonyms: FRABP, ZFYVE6, Frabin