Frizzled 6 (FZD6) (Center) Rabbit Polyclonal Antibody

CAT#: AP51749PU-N

Frizzled 6 (FZD6) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of FZD6 Antibody (Center) in A549 cell line lysates (35ug/lane). This demonstrates the FZD6 antibody detected the FZD6 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human FZD6
• Specificity: This antibody recognizes Human FZD6 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens frizzled class receptor 6 (FZD6), transcript variant 2
• Database Link:
  Entrez Gene 8323 Human
• Background: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.
• Synonyms: Frizzled-6, Fz-6, hFz6
• Note: Molecular Weight: 79292 Da

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway