GLDC (N-term) Rabbit Polyclonal Antibody

CAT#: AP51849PU-N

GLDC (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of GLDC Antibody (N-term) in mouse liver tissue lysates (35ug/lane). GLDC (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.

• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 56~85 amino acids from the N-terminal region of Human GLDC
• Specificity: This antibody recpognizes Human and Mouse GLDC (N-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens glycine dehydrogenase (decarboxylating) (GLDC)
• Database Link:
  Entrez Gene 104174 MouseEntrez Gene 2731 Human
• Background:
  Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
• Synonyms: GCSP, Glycine cleavage system P protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring), Glycine dehydrogenase (decarboxylating), mitochondrial
• Note: Molecular Weight: 112730 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Glycine, serine and threonine metabolism, Metabolic pathways