Gremlin 1 (GREM1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP51947PU-N

Gremlin 1 (GREM1) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of GREM1 (arrow) using Gremlin-1 / GREM1 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GREM1 gene.

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 110-139 amino acids from the C-terminal region of Human Gremlin-1 / GREM1
• Specificity: This antibody recognizes Human Gremlin-1 / GREM1 (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens gremlin 1, DAN family BMP antagonist (GREM1), transcript variant 2
• Database Link:
  Entrez Gene 26585 Human
• Background: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: DAND2, CKTSF1B1, DRM, PIG2, IHG-2, GREM-1
• Note: Molecular Weight: 20697 Da

Reference Data

• Protein Families: ES Cell Differentiation/IPS, Secreted Protein