HSD11B2 (Center) Rabbit Polyclonal Antibody

CAT#: AP52107PU-N

HSD11B2 (Center) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications FC, IHC, WB
Recommended Dilution This antibody is suitable for Western Blotting, Flow cytometry and Paraffin sections.
The suggested dilution is:
ELISA: 1:1;000
Western blotting: 1:100~500
Immunohistochemistry: 1:50~100
Flow cytometry: 1:10~50
Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 284~314 amino acids from the Central region of human HSD11B2.
Formulation Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
State: Aff - Purified
State: Liquid
Concentration lot specific
Purification This antibody is purified through a protein A column; followed by peptide affinity purification.
Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene Name Homo sapiens hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2)
Background There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Synonyms 11-beta-hydroxysteroid dehydrogenase 2, HSD11K, 11-DH2
Note Molecular Weight: 44127 Da
Reference Data
Protein Families Druggable Genome
Protein Pathways Androgen and estrogen metabolism, C21-Steroid hormone metabolism, Metabolic pathways

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.