Hydroxysteroid (17 beta) Dehydrogenase 4 (HSD17B4) (Center) Rabbit Polyclonal Antibody

CAT#: AP52112PU-N

Hydroxysteroid (17 beta) Dehydrogenase 4 (HSD17B4) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of 17-beta-HSD4 / HSD17B4 Antibody (Center) in MCF-7, ZR-75-1, HepG2 cell line lysates (35ug/lane). This demonstrates the HSD17B4 antibody detected the HSD17B4 protein (arrow).

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with 17-beta-HSD4 / HSD17B4 Antibody (Center), which was peroxidase conjugated to the secondary antibody and followed by DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 340-370 amino acids from the Central region of human 17-beta-HSD4 / HSD17B4
• Specificity: This antibody recognizes Human 17-beta-HSD4 / HSD17B4 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4), transcript variant 2
• Database Link:
  Entrez Gene 3295 Human
• Background: The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. [provided by RefSeq].
• Synonyms: MFE-2, DBP, SDR8C1, EDH17B4, MFE2
• Note: Molecular Weight: 79686 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Primary bile acid biosynthesis