CTLA4 (N-term) Rabbit Polyclonal Antibody

CAT#: AP52146PU-N

CTLA4 Antibody (N-term)

Product Images

Western blot analysis of CD152 / CTLA4 Antibody (N-term) in WiDr cell line lysates (35ug/lane).

• 

  Formalin fixed and paraffin embedded human prostate carcinoma reacted with CD152 / CTLA4 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Clone Name: RB23352
• Applications: IHC, WB
• Recommended Dilution: WB 1:2000
  WB 1:2000
  IHC-P 1:50~100
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 50-78 amino acids from the N-terminal region of Human CD152 / CTLA4.
• Specificity: This IDDM12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids of human IDDM12.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 24656 kDa
• Gene Name: cytotoxic T-lymphocyte associated protein 4
• Database Link:
  NP_001032720.1
  Entrez Gene 1493 Human
  UniProt ID P16410
• Background: CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
• Synonyms: CTLA-4

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway