IL10 (Center) Rabbit Polyclonal Antibody

CAT#: AP52181PU-N

IL10 (Center) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications FC, IHC, WB
Recommended Dilution Flow Cytometry:  1/10-1/50.
Immunohistochemistry on Paraffin Sections:  1/10-1/50.
Western blotting: 1/1000.
Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated corresponding to the center region (between aa 27-53) of Human IL10.
Specificity This antibody detects Human IL10.
Other species not tested.
Formulation PBS with 0.09% (W/V) Sodium Azide.
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Purified through a protein A column; followed by peptide affinity purification.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens interleukin 10 (IL10)
Background Interleukin-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Synonyms IL-10, CSIF, TGIF
Note Molecular Weight: 20517 Da
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.