IL12B (C-term) Rabbit Polyclonal Antibody

CAT#: AP52183PU-N

IL12B (C-term) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Other products for "IL12B"

Specifications

Product Data
Applications FC, IHC, WB
Recommended Dilution

This antibody is suitable for flow cytometry, immunohistochemistry on paraffin sections and Western blotting.
The suggested dilution is:
Flow cytometry: 1/10-1/50.
Immunohistochemistry on paraffin sections: 1/50-1/100.
Western blotting: 1/100-1/500.

Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 271-298aa) of human Interleukin-12 beta/IL12B.
Specificity This antibody detects human Interleukin-12 beta/IL12Bat C-term.
Formulation PBS with 0.09% (W/V) Sodium Azide.
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Purified through a protein A column; followed by peptide affinity purification.
Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Gene Name Homo sapiens interleukin 12B (IL12B)
Background IL12B is a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Synonyms Interleukin-12B, IL-12B, IL-12 subunit p40, CLMF p40, NKSF2
Note Molecular Weight: 37169 Da
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Allograft rejection, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.