IL12RB2 (C-term) Rabbit Polyclonal Antibody

CAT#: AP52184PU-N

IL12RB2 (C-term) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications FC, IHC, WB
Recommended Dilution

This antibody is suitable for flow cytometry, immunohistochemistry on paraffin sections and Western blotting.
The suggested dilution is:
Flow cytometry: 1/10-1/50.
Immunohistochemistry on paraffin sections: 1/50-1/100.
Western blotting: 1/100-1/500.

Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 759-788aa) of human IL12RB2.
Specificity This antibody detects human IL12RB2 at C-term.
Formulation PBS with 0.09% (W/V) Sodium Azide.
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Purified through a protein A column; followed by peptide affinity purification.
Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Gene Name Homo sapiens interleukin 12 receptor, beta 2 (IL12RB2), transcript variant 1
Background The protein encoded by the IL12RB2 gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
Synonyms IL-12 receptor beta-2, IL-12R-beta-2
Note Molecular Weight: 97135 Da
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.