IL1 Receptor II (IL1R2) (Center) Rabbit Polyclonal Antibody

CAT#: AP52192PU-N

IL1 Receptor II (IL1R2) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in WiDr cell line lysates (35ug/lane) using CD121b / IL1R2 antibody. This demonstrates the IL1R2 antibody detected the IL1R2 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution:

  Western blot: 1/100-1/500.
  Enzyme immunoassay: 1/1000.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the central region (between 273-300aa) of human CD121b / IL1R2.
• Specificity: This antibody recognizes CD121b / IL1R2.
• Formulation: PBS with 0.09% (W/V) Sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a Protein A column followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens interleukin 1 receptor type 2 (IL1R2), transcript variant 1
• Database Link:
  Entrez Gene 7850 Human
• Background: The protein encoded by the IL1R2 gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.
• Synonyms: Interleukin-1 receptor type II, IL-1R-2, IL-1R-beta, CDw121b, IL1RB
• Note: Molecular Weight: 45421 Da

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway