MUM1 (IRF4) (Center) Rabbit Polyclonal Antibody

CAT#: AP52236PU-N

MUM1 (IRF4) (Center) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of IRF4 (arrow) using IRF4 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the IRF4 gene.

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  Flow cytometric analysis of 293 cells using IRF4 Antibody (Center) (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Flow Cytometry: 1/10-1/50.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 171-199 amino acids from the Central region of human IRF4
• Specificity: This antibody recognizes Human IRF4 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens interferon regulatory factor 4 (IRF4), transcript variant 2
• Database Link:
  Entrez Gene 3662 Human
• Background: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
• Synonyms: Interferon regulatory factor 4, NF-EM5, MUM1, LSIRF
• Note: Molecular Weight: 51772 Da

Reference Data

• Protein Families: Druggable Genome, Transcription Factors