ITGA8 (C-term) Rabbit Polyclonal Antibody

CAT#: AP52252PU-N

ITGA8 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Integrin alpha-8 / ITGA8 Antibody (C-term) in K562 cell line lysates (35ug/lane). This demonstrates the ITGA8 antibody detected the ITGA8 protein (arrow).

• 

  Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue reacted with Integrin alpha-8 / ITGA8 Antibody (C-term), which was peroxidase conjugated to the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/50-1/100.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 1032-1061 amino acids from the C-terminal region of human ITGA8
• Specificity: This antibody recognizes Human Integrin alpha-8 / ITGA8 (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens integrin subunit alpha 8 (ITGA8), transcript variant 1
• Database Link:
  Entrez Gene 8516 Human
• Background: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
• Synonyms: ITGA8
• Note: Molecular Weight: 117474 Da

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton