KCNA1 (Center) Rabbit Polyclonal Antibody

CAT#: AP52298PU-N

KCNA1 (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of KCNA1 Antibody (Center) in Hela cell line lysates (35ug/lane). This demonstrates the KCNA1 antibody detected the KCNA1 protein (arrow).

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissuereacted with KCNA1 Antibody (Center), which was peroxidase conjugated to the secondary antibody and followed by DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 171-201 amino acids from the Central region of human KCNA1
• Specificity: This antibody recognizes Human KCNA1 (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens potassium voltage-gated channel subfamily A member 1 (KCNA1)
• Database Link:
  Entrez Gene 3736 Human
• Background: This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).
• Synonyms: HUKI, HBK1
• Note: Molecular Weight: 56466 Da

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Potassium, Transmembrane