KIDINS220 (C-term) Rabbit Polyclonal Antibody

CAT#: AP52362PU-N

KIDINS220 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of ARMS / KIDINS220 Antibody (C-term) in K562 cell line lysates (35ug/lane). This demonstrates the KIDINS220 antibody detected the KIDINS220 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 1517-1547 amino acids from the C-terminal region of Human ARMS / KIDINS220
• Specificity: This antibody recognizes Human ARMS / KIDINS220 (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens kinase D-interacting substrate 220kDa (KIDINS220)
• Database Link:
  Entrez Gene 57498 Human
• Background: KIDINS220 promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
• Synonyms: KIAA1250
• Note: Molecular Weight: 196542 Da

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Neurotrophin signaling pathway