NKG2A (KLRC1) (N-term) Rabbit Polyclonal Antibody

CAT#: AP52396PU-N

NKG2A (KLRC1) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of KLRC1 / CD159a Antibody (N-term) in MDA-MB435 cell line lysates (35ug/lane). This demonstrates the KLRC1 antibody detected the KLRC1 protein (arrow).

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  Confocal immunofluorescent analysis of KLRC1 / CD159a Antibody (N-term) with MDA-MB435 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western Blot: 1/1000.
  Immunofluorescence: 1/10-1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KLRC1 / CD159a
• Specificity: This antibody recognizes Human KLRC1 / CD159a (N-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens killer cell lectin like receptor C1 (KLRC1), transcript variant 1
• Database Link:
  Entrez Gene 3821 Human
• Background:
  Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq].
• Synonyms: KLRC1, NKG2A, NKG2-A/B-activating NK receptor, NK cell receptor A, CD159 antigen-like family member A, CD159a
• Note: Molecular Weight: 26287 Da

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Antigen processing and presentation, Graft-versus-host disease, Natural killer cell mediated cytotoxicity