KSR2 (C-term) Rabbit Polyclonal Antibody

CAT#: AP52428PU-N

KSR2 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

KSR2 Antibody (C-term) western blot analysis in 293, K562, HepG2, Hela cell line lysates (35ug/lane).This demonstrates the KSR2 antibody detected the KSR2 protein (arrow).

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  KSR2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KSR2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

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  KSR2 Antibody (C-term) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western blot: 1/100 -1/500.
  Immunohistochemistry: 1/50 - 1/100.
  Flow Cytometry: 1/10 - 1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human KSR2
• Specificity: This antibody reacts to KSR2.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 107632 Da
• Gene Name: Homo sapiens kinase suppressor of ras 2 (KSR2)
• Database Link:
  Entrez Gene 283455 Human
• Background: Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
• Synonyms: KSR2, KSR-2, hKSR2, hKSR-2

Reference Data

• Protein Families: Druggable Genome, Protein Kinase