Leucyl cystinyl aminopeptidase (LNPEP) (N-term) Rabbit Polyclonal Antibody

CAT#: AP52510PU-N

Leucyl cystinyl aminopeptidase (LNPEP) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of LNPEP Antibody (N-Term) in HL-60 cell line lysates (35ug/lane). This demonstrates the LNPEP antibody detected the LNPEP protein (arrow).

• 

  Formalin fixed, paraffin embedded Human kidney tissue stained with LNPEP Antibody (N-Term) followed by peroxidase conjugation of the secondary antibody and DAB staining.

• 

  Flow cytometric analysis of HL-60 cells using LNPEP Antibody (N-Term) (right histogram) compared to a negative control cell (left histogram). FITC-conjugated Goat anti Rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: ELISA: 1/1000
  Western Blot: 1/100-1/500.
  Flow Cytometry: 1/10-1/50.
  Immunohistochemistry on Paraffin Sections: 1/50-1/100.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of Human LNPEP.
• Specificity: This antibody recognizes Human LNPEP (N-Term).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens leucyl and cystinyl aminopeptidase (LNPEP), transcript variant 1
• Database Link:
  Entrez Gene 4012 Human
• Background:
  This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
• Synonyms: LNPEP, OTASE, Leucyl-cystinyl aminopeptidase, Cystinyl aminopeptidase, EC=3.4.11.3, Oxytocinase, Insulin-responsive aminopeptidase, IRAP, Placental leucine aminopeptidase, P-LAP
• Note: Molecular Weight: 117349 Da

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane
• Protein Pathways: Renin-angiotensin system