MCM7 (N-term) Rabbit Polyclonal Antibody

CAT#: AP52641PU-N

MCM7 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of MCM7 Antibody (N-term) in Jurkat cell line lysates (35ug/lane). This demonstrates the MCM7 antibody detected the MCM7 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 113-142 amino acids from the N-terminal region of human MCM7
• Specificity: This antibody recognizes Human MCM7 (N-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: minichromosome maintenance complex component 7
• Database Link:
  Entrez Gene 4176 Human
  UniProt ID P33993
• Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Synonyms: CDC47, MCM2, CDC47 homolog, P1.1-MCM3
• Note: Molecular Weight: 81308 Da

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Cell cycle, DNA replication