E3 ubiquitin protein ligase MUL1 (MUL1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP52776PU-N

E3 ubiquitin protein ligase MUL1 (MUL1) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in human placenta tissue lysates (35ug/lane) using MUL1 / RNF218 antibody. (C-term). This demonstrates this antibody detected the MUL1 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/1000.
  Enzyme immunoassay: 1/1000.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 272-301 aa) of human MUL1 / RNF218
• Specificity: This antibody recognizes MUL1 / RNF218 at C-term.
• Formulation: PBS with 0.09% (W/V) Sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a Protein A column followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens mitochondrial E3 ubiquitin protein ligase 1 (MUL1)
• Database Link:
  Entrez Gene 79594 Human
• Background: E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
• Synonyms: C1orf166, GIDE, MAPL, MULAN, RING finger protein 218
• Note: Molecular Weight: 39800 Da

Reference Data

• Protein Families: Druggable Genome, Transmembrane