MAD3 (MXD3) (N-term) Rabbit Polyclonal Antibody

CAT#: AP52781PU-N

MAD3 (MXD3) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in K562 cell line lysates (35ug/lane) using MAD3 antibody. (N-term). This demonstrates this antibody detected the MAD3 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/100-1/500.
  Enzyme immunoassay: 1/1000.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 27-56aa) of human MAD3
• Specificity: This antibody recognizes human MAD3 at N-term.
• Formulation: PBS with 0.09% (W/V) Sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a Protein A column followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens MAX dimerization protein 3 (MXD3), transcript variant 2
• Database Link:
  Entrez Gene 83463 Human
• Background: The MXD3 gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The Max-associated protein 3 / MAD3 forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.
• Synonyms: MAD-3, MXD3,Max-interacting transcriptional repressor MAD3
• Note: Molecular Weight: 23477 Da

Reference Data

• Protein Families: Druggable Genome, Transcription Factors