Neutrophil Elastase (ELANE) (N-term) Rabbit Polyclonal Antibody

CAT#: AP52858PU-N

Neutrophil Elastase (ELANE) (N-term) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications WB
Recommended Dilution

Western blot: 1/1000.
Enzyme immunoassay: 1/1000.

Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated -  between 13-39 amino acids from the N-terminal region (between 20-47aa ) of human Neutrophil elastase
Specificity This antibody recognizes human Neutrophil elastase at N-term.
Formulation PBS with 0.09% (W/V) Sodium azide
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Purified through a Protein A column followed by peptide affinity purification
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Gene Name Homo sapiens elastase, neutrophil expressed (ELANE)
Background Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Synonyms ELANE, ELA2, Neutrophil elastase, Elastase-2, PMN elastase, Bone marrow serine protease, Medullasin, Human leukocyte elastase, HLE
Note Molecular Weight: 28518 Da
Reference Data
Protein Families Protease, Transmembrane
Protein Pathways Systemic lupus erythematosus

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.